Lithium has been used for decades to treat bipolar disorders when the manic episodes during Manic Depression. With the development of SSRIs (Selective Serotonin Reuptake Inhibitors), it was thought that lithium would no longer be needed, as SSRIs always have less severe side ends up in than lithium. This could not happen, as many therapies to accommodate depression and bipolar moodiness that involved an SSRI are now being augmented with lithium.
How does Lithium Make use of an SSRI?
Lithium is within the nfl common substances used combination with SSRIs. The method the place lithium works is inside the altering of the commuter routes of sodium throughout nerve and muscle tissue. It is sodium that within major role in the excitability of their suffering manic episodes while he deal with Manic Depression and bipolar disorder.
The dosing of lithium is used extensively in maintenance mindsets, by reducing the associated with manic episodes and, as a means of maintenance dosing, to help in the prevention of manic episodes and bipolar disorder symptoms. There is, any way, the possibility of a negative interaction by using lithium not to mention an SSRI. Lithium can add additional serotonin regulatory effects of SSRIs to match needed, which can could cause serotonin syndrome, a life - threatening disease.
Effects of Lithium whilst on SSRI Treatment
Though lithium certainly are a proven treatment in targeted personality disorders, it are available with side effects. These adverse effects are more common, and frequently more severe, than those of SSRIs that's the inspiration for the development of SSRIs. Some of the side effects of lithium are the following:
- Drowsiness
- Excessive Thirst
- Fatigue
- Hand Tremors
- Increased Urination
- Nausea
- Thyroid Problems
- Weakness
- Weight Gain
Interactions with Lithium whilst on SSRI Therapy
There has been some cause for concern when augmenting SSRI coaching with lithium. Lithium has become known to interact negatively from your fluoxetine, an SSRI known by several brand names most commonly Prozac. Of all the contemporary SSRIs, citalopram (Celexa) has had a minimum of complications due to interactions for other drugs and has not which can have any adverse affects in combination with Lithium.
The most common and worrisome complication in interactions between SSRIs and finished lithium is serotonin problem. Serotonin syndrome is simply much more of serotonin that gathers in the the particular body. The excess serotonin is a result of over stimulation from drugs that are employed regulate serotonin levels by the body processes, such as an SSRI. It's really caused simply by an overdose connected with an SSRI, or by taking other substances, such with lithium, in concert that have an SSRI.
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